Trifluoroacetic Acid (TFA)
Trifluoroacetic Acid (TFA)
Trifluoroacetic Acid (TFA) is a high-purity, colorless, fuming organic acid widely used in pharmaceuticals, peptide chemistry, analytical chemistry (HPLC/LC–MS), and polymer modification. It is a strong perfluorinated carboxylic acid known for excellent solubility and exceptional reactivity in organic synthesis.
- High purity 99–99.9% available.
- Widely used in peptide deprotection and pharmaceutical synthesis.
- Excellent modifier for HPLC and LC–MS mobile phases.
TFA is produced through electrofluorination and advanced fluorochemical processes. Due to its strong acidity and reactivity, it is used across multiple industries including pharmaceuticals, polymers, fluorochemical manufacturing, and advanced laboratory applications.
Applications & Key Features
Trifluoroacetic Acid is valued for its strong protonating ability, low boiling point, and ability to enhance chromatographic separation. Its exceptional purity makes it suitable for advanced chemical research and industrial production.
- Ideal reagent for peptide, DNA, and RNA synthesis.
- Solvent for polyamides, peptides, and PTFE modification.
- Used in esterification, acylation, and fluorochemical synthesis.
Technical Data Sheet (TDS)
| Parameter | Specification | Result |
|---|---|---|
| Chemical Name | Trifluoroacetic Acid (TFA) | Confirmed |
| CAS Number | 76-05-1 | Verified |
| Chemical Formula | C₂HF₃O₂ | Correct |
| Appearance | Colorless, fuming liquid | Matches |
| Purity | 99–99.9% | 99.5% |
| Boiling Point (°C) | 71–72°C | Within Range |
| Melting Point (°C) | –15.4°C | –15°C |
| Density (20°C) | 1.489 g/mL | 1.49 g/mL |
| pKa | ~0.23 | 0.23 |
| Refractive Index | 1.289 | 1.289 |
| Vapor Pressure | 12–13 mmHg (20°C) | 12.5 mmHg |
| Solubility | Miscible with water & organics | Pass |
| Flash Point | Non-flammable | Non-flammable |
| Corrosivity | Highly corrosive | Confirmed |
| Decomposition | CO₂, HF, CO | As Expected |
| UN Number | UN 2699 | Verified |
| Hazard Class | 8 – Corrosive | Correct |
| Packing Group | II | II |
| Inspection | SGS | Available |
Why Choose Our Trifluoroacetic Acid (TFA)?
- High-purity grades (99–99.9%) suitable for pharmaceutical, peptide, and analytical applications.
- Excellent reagent for peptide deprotection, esterification, and advanced organic synthesis.
- Highly effective mobile phase modifier for HPLC and LC–MS, improving peak shape and ionization.
- Ultra-clean production ensures low water content, ideal for critical research and industrial use.
- Available in multiple packaging sizes for laboratory, pilot, and bulk industrial requirements.
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